Manchester United manager Erik ten Hag is concerned his team are “not ready” for Friday’s Premier League opener against Fulham (20:00 BST).
New signings Matthijs de Ligt and Noussair Mazraoui will be in the squad but only arrived on Thursday.
They have had a limited chance to train with their new team-mates, leaving Ten Hag with a selection dilemma for the match at Old Trafford.
Meanwhile, defender Luke Shaw has been sidelined with a calf injury, new £52m defender Leny Yoro was ruled out for three months at the beginning of August, and forward Rasmus Hojlund has a hamstring problem.
United committed to spending close to £60m by bringing defenders De Ligt and Mazraoui to the club from Bayern Munich.
“The team is not ready but the league starts,” said Ten Hag.
“We can’t hide from it. We have to deal with it.”
United’s other summer signing, Netherlands striker Joshua Zirkee, was an unused substitute during the Community Shield defeat by Manchester City and could make his debut against Fulham.